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fda.gov

U S Food and Drug Administration - Potential Signals of Serious Risks/New Safety Information Identified by the Adverse Event Reporting Syste

Increase in blood creatine phosphokinase levels and rhabdomyolysis. The Adverse Reactions section of the labeling for Neurontin was updated May 2013, to include increase in blood creatine phosphokinase levels and rhabdomyolysis. Gabapentin HCl (Neurontin) Labeling approved May 1, 2013 (PDF - 288KB

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National Library of Medicine - Creatine - MedlinePlus Supplements
However, a connection between high doses and these negative effects has not been proven. There is some concern that combining creatine with caffeine and the herb ephedra (also called Ma Huang) might increase the chance of having serious side effects such as stroke. Stay on the safe side and avoid